Study challenges mad cow research

Researchers have found more evidence that a virus may cause mad cow disease and a related brain disorder in humans, threatening to overturn 25 years of research focusing on malformed proteins called prions.

Nerve cells infected with the human form of mad cow disease contained a virus-sized particle that doesn't appear in uninfected cells, said Laura Manuelidis, a neuropathologist at Yale Medical School in New Haven, Conn. Cells infected with scrapie, a sheep disorder related to mad cow disease, contained the same germ.

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